{"id":859,"date":"2026-05-06T15:27:19","date_gmt":"2026-05-06T13:27:19","guid":{"rendered":"https:\/\/cienciaytecnology.com\/wordpress\/?p=859"},"modified":"2026-05-06T15:30:55","modified_gmt":"2026-05-06T13:30:55","slug":"hantavirus","status":"publish","type":"post","link":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/","title":{"rendered":"Hantavirus"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Informaci\u00f3n evidencia<\/h2>\n\n\n\n<p>El&nbsp;<strong>Virus Andes (Andes orthohantavirus, ANDV)<\/strong>&nbsp;es un&nbsp;<strong>orthohantavirus zoon\u00f3tico<\/strong>&nbsp;que causa el&nbsp;<strong>s\u00edndrome cardiopulmonar por hantavirus (SCPH)<\/strong>&nbsp;en humanos, una enfermedad grave con una&nbsp;<strong>tasa de letalidad del 20-45%<\/strong>. Es end\u00e9mico en&nbsp;<strong>Chile y el sur de Argentina<\/strong>, donde ocurren brotes estacionales anuales.&nbsp;[1-2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Caracter\u00edsticas virol\u00f3gicas<\/h2>\n\n\n\n<p>El ANDV pertenece al g\u00e9nero Orthohantavirus, familia Hantaviridae, orden Bunyavirales. Es un virus envuelto de 80-120 nm de di\u00e1metro con un genoma de ARN de cadena negativa segmentado en tres partes: segmento peque\u00f1o (S) que codifica la nucleoc\u00e1pside, segmento mediano (M) que codifica las glicoprote\u00ednas de envoltura (Gn y Gc), y segmento grande (L) que codifica la ARN polimerasa dependiente de ARN.&nbsp;[2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Reservorio y transmisi\u00f3n<\/h2>\n\n\n\n<p><strong>Reservorio natural:<\/strong>&nbsp;El principal reservorio es el roedor&nbsp;<strong>Oligoryzomys longicaudatus<\/strong>&nbsp;(colilargo), presente en \u00e1reas rurales del centro y sur de Chile.&nbsp;[1]&nbsp;Otras especies de roedores sigmodontinos tambi\u00e9n pueden albergar el virus, incluyendo Abrothrix longipilis, Abrothrix olivaceus y Loxodontomys micropus.&nbsp;[3-4]<\/p>\n\n\n\n<p><strong>V\u00edas de transmisi\u00f3n:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Zoon\u00f3tica (principal):<\/strong>\u00a0Inhalaci\u00f3n de aerosoles contaminados con orina, heces o saliva de roedores infectados\u00a0[1-2]<\/li>\n\n\n\n<li><strong>Persona a persona (\u00fanica entre hantavirus):<\/strong>\u00a0El ANDV es excepcional entre los hantavirus por su capacidad de transmisi\u00f3n interhumana, documentada epidemiol\u00f3gica y molecularmente en Argentina y Chile. La transmisi\u00f3n ocurre principalmente por contacto cercano e \u00edntimo con personas sintom\u00e1ticas, especialmente parejas sexuales (riesgo 17.6% vs 1.2% para otros contactos dom\u00e9sticos)\u00a0[1-2][5]<\/li>\n<\/ul>\n\n\n\n<p>Un estudio prospectivo de 2024 demostr\u00f3 que el ANDV se excreta en fluido crevicular gingival, saliva y secreciones nasofar\u00edngeas hasta 16 d\u00edas despu\u00e9s del inicio de s\u00edntomas, apoyando la transmisi\u00f3n por v\u00edas respiratorias y salivales.&nbsp;[1]&nbsp;Estudios ultraestructurales muestran replicaci\u00f3n viral en epitelio alveolar pulmonar, macr\u00f3fagos y gl\u00e1ndulas salivales submandibulares.&nbsp;[6]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Epidemiolog\u00eda<\/h2>\n\n\n\n<p><strong>Distribuci\u00f3n geogr\u00e1fica:<\/strong>&nbsp;Chile (regiones de Coquimbo a Ays\u00e9n, 30-46\u00b0S) y sur de Argentina.&nbsp;[2][4]&nbsp;Se diagnostican aproximadamente 300 casos de SCPH anuales en las Am\u00e9ricas, principalmente en Argentina, Brasil y Chile.&nbsp;[2]<\/p>\n\n\n\n<p><strong>Poblaci\u00f3n afectada:<\/strong>&nbsp;Edad mediana 34 a\u00f1os (rango 0-86), 70-80% hombres. El 80% de casos ocurren en residentes de \u00e1reas end\u00e9micas rurales, 20% en visitantes.&nbsp;[2]<\/p>\n\n\n\n<p><strong>Factores de riesgo:<\/strong>&nbsp;Trabajo forestal o agr\u00edcola, deshierbe, construcci\u00f3n, demolici\u00f3n, limpieza de casas previamente desocupadas, actividades que levantan polvo en s\u00f3tanos, \u00e1reas de almacenamiento o establos.&nbsp;[2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Brotes notables de transmisi\u00f3n persona a persona<\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/storage.googleapis.com\/nejm-multimedia\/cms\/10.1056\/NEJMoa2009040\/asset\/151d384f-dd36-4f6f-86f6-fe77978b7950\/assets\/images\/large\/NEJMoa2009040_f1.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p>Figure 1.&nbsp;Epidemiologic Analysis of the 2018\u22122019 Outbreak of Andes Virus (ANDV) Hantavirus Pulmonary Syndrome and Transmission Dynamics in Humans.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2009040\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cSuper-Spreaders\u201d and Person-to-Person Transmission of Andes Virus in Argentina.<\/a>&nbsp;N Engl J Med.&nbsp;3 de diciembre de 2020.<\/p>\n\n\n\n<p>Used under license from The New England Journal of Medicine.<\/p>\n\n\n\n<p>La figura muestra el an\u00e1lisis epidemiol\u00f3gico del brote de Epuy\u00e9n 2018-2019, que afect\u00f3 a 34 pacientes con 11 muertes. El an\u00e1lisis filogen\u00e9tico demostr\u00f3 que todos los casos se agruparon como un \u00fanico evento de introducci\u00f3n zoon\u00f3tica, seguido de transmisi\u00f3n sostenida persona a persona impulsada por tres \u00absupercontagiadores\u00bb que asistieron a eventos sociales masivos mientras estaban sintom\u00e1ticos.&nbsp;[5]<\/p>\n\n\n\n<p><strong>Brotes hist\u00f3ricos importantes:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1996, El Bols\u00f3n, Argentina:<\/strong>\u00a0Primer brote documentado con transmisi\u00f3n persona a persona (16 casos epidemiol\u00f3gicamente vinculados)\u00a0[5]<\/li>\n\n\n\n<li><strong>2018-2019, Epuy\u00e9n, Argentina:<\/strong>\u00a034 casos confirmados, 11 muertes. El n\u00famero reproductivo (R) alcanz\u00f3 6.5 durante eventos de supercontagio, pero disminuy\u00f3 de 2.12 a 0.96 tras implementar aislamiento y cuarentena\u00a0[5]<\/li>\n<\/ul>\n\n\n\n<p>Los estudios gen\u00f3micos muestran que las cepas Epuy\u00e9n\/18-19 y Epilink\/96, separadas por 22 a\u00f1os, tienen m\u00ednima divergencia gen\u00e9tica, sugiriendo que los rasgos que permiten la transmisi\u00f3n persona a persona se mantienen en poblaciones de reservorios sin necesidad de adaptaci\u00f3n viral.&nbsp;[5]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Manifestaciones cl\u00ednicas<\/h2>\n\n\n\n<p><strong>Per\u00edodo de incubaci\u00f3n:<\/strong>&nbsp;Promedio de 18 d\u00edas (rango 5-50 d\u00edas).&nbsp;[1-2]<\/p>\n\n\n\n<p><strong>Espectro cl\u00ednico:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Enfermedad subcl\u00ednica o leve:<\/strong>\u00a0S\u00edntomas inespec\u00edficos iniciales (fiebre, mialgias, cefalea)<\/li>\n\n\n\n<li><strong>SCPH grave (>50% de casos):<\/strong>\u00a0Compromiso severo de pulmones y coraz\u00f3n, los dos \u00f3rganos diana principales\u00a0[1]<\/li>\n<\/ul>\n\n\n\n<p><strong>Fisiopatolog\u00eda:<\/strong>&nbsp;Las c\u00e9lulas endoteliales de capilares y vasos peque\u00f1os son los principales objetivos del virus. El aumento de la permeabilidad vascular es central en la patog\u00e9nesis, causando edema pulmonar de inicio r\u00e1pido por fuga microvascular, seguido de shock cardiog\u00e9nico.&nbsp;[1-2]<\/p>\n\n\n\n<p><strong>Viremia:<\/strong>&nbsp;El ARN de ANDV puede detectarse en sangre hasta 2 semanas antes del inicio de s\u00edntomas y durante la enfermedad sintom\u00e1tica, persistiendo semanas despu\u00e9s de la resoluci\u00f3n de s\u00edntomas.&nbsp;[2]<\/p>\n\n\n\n<p><strong>Letalidad:<\/strong>&nbsp;20-35% en casos reportados en Chile y Argentina.&nbsp;[1]&nbsp;En Argentina, la tasa de letalidad ha mostrado tendencia a la disminuci\u00f3n desde 1995, pasando de 21-50% a 21.4% en el per\u00edodo 2009-2017.&nbsp;[5][7]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Diagn\u00f3stico<\/h2>\n\n\n\n<p><strong>Sospecha cl\u00ednica:<\/strong>&nbsp;Pacientes con residencia o viaje reciente (5-50 d\u00edas) a regi\u00f3n end\u00e9mica, presentando fiebre persistente (&gt;48h), cefalea, mialgias, manifestaciones gastrointestinales (dolor abdominal, v\u00f3mitos, diarrea) y disminuci\u00f3n marcada de plaquetas. En enfermedad avanzada: tos, disnea, hipoxia e infiltrados pulmonares bilaterales.&nbsp;[2]<\/p>\n\n\n\n<p><strong>En regiones end\u00e9micas de ANDV:<\/strong>&nbsp;Contacto cercano con paciente infectado en los 40 d\u00edas previos, particularmente contacto sexual o dormir en la misma habitaci\u00f3n, debe considerarse factor de riesgo.&nbsp;[2]<\/p>\n\n\n\n<p><strong>M\u00e9todos diagn\u00f3sticos:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Serolog\u00eda (m\u00e1s utilizada):<\/strong>\u00a0Anticuerpos IgM contra prote\u00edna nucleoc\u00e1pside presentes al inicio del pr\u00f3dromo febril; IgG presentes al final del pr\u00f3dromo. M\u00e9todo est\u00e1ndar: ELISA\u00a0[2]<\/li>\n\n\n\n<li><strong>RT-qPCR:<\/strong>\u00a0Sensible y espec\u00edfico, dise\u00f1ado para detectar segmento S. Cargas virales m\u00e1s altas en capa leucocitaria que en plasma. Puede detectar ARN de ANDV hasta 2 semanas antes del inicio de s\u00edntomas y semanas despu\u00e9s de resoluci\u00f3n\u00a0[2]<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Tratamiento<\/h2>\n\n\n\n<p><strong>No existe tratamiento antiviral espec\u00edfico aprobado<\/strong>. El manejo es de soporte avanzado.&nbsp;[2]<\/p>\n\n\n\n<p><strong>Soporte cr\u00edtico:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Monitoreo cuidadoso de signos cl\u00ednicos, balance hidroelectrol\u00edtico, presi\u00f3n arterial y producci\u00f3n de orina<\/li>\n\n\n\n<li>Oxigenaci\u00f3n, ventilaci\u00f3n mec\u00e1nica si necesario<\/li>\n\n\n\n<li>F\u00e1rmacos vasoactivos junto con fluidos para hipotensi\u00f3n y shock<\/li>\n\n\n\n<li><strong>ECMO veno-arterial:<\/strong>\u00a0Frecuentemente requerido dado el patr\u00f3n hemodin\u00e1mico \u00fanico del SCPH (hipovolemia, disfunci\u00f3n sist\u00f3lica y edema pulmonar por aumento de permeabilidad)\u00a0[2][8]<\/li>\n<\/ul>\n\n\n\n<p><strong>Terapias experimentales:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Ribavirina:<\/strong>\u00a0Efectiva en modelos animales de ANDV cuando se administra antes del inicio de viremia. Un ensayo cl\u00ednico peque\u00f1o en fase cardiopulmonar no mostr\u00f3 beneficio de supervivencia\u00a0[2][9]<\/li>\n\n\n\n<li><strong>Favipiravir:<\/strong>\u00a0Efectivo en modelos animales de ANDV y SNV cuando se administra antes de viremia\u00a0[2]<\/li>\n\n\n\n<li><strong>Plasma convaleciente:<\/strong>\u00a0En estudio abierto en Chile, la mortalidad en pacientes tratados fue menor que en grupos de comparaci\u00f3n no aleatorizados\u00a0[2]<\/li>\n\n\n\n<li><strong>Anticuerpos monoclonales:<\/strong>\u00a0Resultados prometedores in vitro y en modelos animales\u00a0[2][10]<\/li>\n\n\n\n<li><strong>Icatibant (antagonista del receptor de bradicinina):<\/strong>\u00a0Usado en varios pacientes con HFRS grave\u00a0[2]<\/li>\n<\/ul>\n\n\n\n<p><strong>Recomendaci\u00f3n clave:<\/strong>&nbsp;Pacientes con SCPH sospechado, presuntivo o confirmado deben transferirse a centro con unidades de cuidados cr\u00edticos y acceso a ECMO.&nbsp;[2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Prevenci\u00f3n y control<\/h2>\n\n\n\n<p><strong>Medidas de salud p\u00fablica:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aislamiento de casos confirmados<\/li>\n\n\n\n<li>Cuarentena de contactos posibles<\/li>\n\n\n\n<li>Uso de equipo de protecci\u00f3n personal apropiado por trabajadores de salud para prevenir transmisi\u00f3n nosocomial\u00a0[5]<\/li>\n<\/ul>\n\n\n\n<p>El brote de Epuy\u00e9n demostr\u00f3 que estas medidas redujeron efectivamente el n\u00famero reproductivo de 2.12 a 0.96, controlando la transmisi\u00f3n.&nbsp;[5]<\/p>\n\n\n\n<p><strong>Profilaxis post-exposici\u00f3n:<\/strong>&nbsp;Se ha propuesto evaluar tratamiento temprano con favipiravir (antes de viremia), ribavirina (con viremia) o anticuerpos neutralizantes para contactos dom\u00e9sticos cercanos de casos de ANDV, personas expuestas tras accidentes de laboratorio de alto riesgo, o en eventos de supercontagio.&nbsp;[2]<\/p>\n\n\n\n<p><strong>Vacunas:<\/strong>&nbsp;No hay vacunas aprobadas para uso en Europa y las Am\u00e9ricas. Se necesitan vacunas seguras y efectivas, especialmente en las Am\u00e9ricas donde circulan hantavirus letales.&nbsp;[2]<\/p>\n\n\n\n<p>\u00bfLe gustar\u00eda explorar las estrategias espec\u00edficas de manejo en cuidados intensivos para pacientes con s\u00edndrome cardiopulmonar por hantavirus, incluyendo los criterios para inicio de ECMO?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38582089\" target=\"_blank\" rel=\"noreferrer noopener\">Viral Shedding and Viraemia of Andes Virus During Acute Hantavirus Infection: A Prospective Study.<\/a><\/li>\n<\/ol>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"18\" height=\"18\" srcset=\"\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=32&amp;q=75 1x, \/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=48&amp;q=75 2x\" src=\"https:\/\/www.openevidence.com\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=48&amp;q=75\">The Lancet. Infectious Diseases. 2024.&nbsp;Ferr\u00e9s M, Mart\u00ednez-Valdebenito C, Henriquez C, et al.<\/p>\n\n\n\n<p>2.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37105214\" target=\"_blank\" rel=\"noreferrer noopener\">Hantavirus in Humans: A Review of Clinical Aspects and Management.<\/a><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"18\" height=\"18\" srcset=\"\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=32&amp;q=75 1x, \/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=48&amp;q=75 2x\" src=\"https:\/\/www.openevidence.com\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.thelancet.com%2F%26sz%3D32&amp;w=48&amp;q=75\">The Lancet. Infectious Diseases. 2023.&nbsp;Vial PA, Ferr\u00e9s M, Vial C, et al.<\/p>\n\n\n\n<p>3.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29929522\" target=\"_blank\" rel=\"noreferrer noopener\">Distributional Ecology of Andes Hantavirus: A Macroecological Approach.<\/a><\/p>\n\n\n\n<p>International Journal of Health Geographics. 2018.&nbsp;Astorga F, Escobar LE, Poo-Mu\u00f1oz D, et al.<\/p>\n\n\n\n<p>4.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19116256\" target=\"_blank\" rel=\"noreferrer noopener\">Ecology, Genetic Diversity, and Phylogeographic Structure of Andes Virus in Humans and Rodents in Chile.<\/a><\/p>\n\n\n\n<p>Journal of Virology. 2009.&nbsp;Medina RA, Torres-Perez F, Galeno H, et al.<\/p>\n\n\n\n<p>5.<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2009040?utm_source=openevidence\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cSuper-Spreaders\u201d and Person-to-Person Transmission of Andes Virus in Argentina.<\/a><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"18\" height=\"18\" srcset=\"\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.nejm.org%2F%26sz%3D32&amp;w=32&amp;q=75 1x, \/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.nejm.org%2F%26sz%3D32&amp;w=48&amp;q=75 2x\" src=\"https:\/\/www.openevidence.com\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fwww.nejm.org%2F%26sz%3D32&amp;w=48&amp;q=75\">The New England Journal of Medicine. 2020.&nbsp;Mart\u00ednez VP, Di Paola N, Alonso DO, et al.<\/p>\n\n\n\n<p>6.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31998273\" target=\"_blank\" rel=\"noreferrer noopener\">Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and\/\u00ador Salivary Pathways.<\/a><\/p>\n\n\n\n<p>Frontiers in Microbiology. 2020.&nbsp;Pizarro E, Navarrete M, Mendez C, et al.<\/p>\n\n\n\n<p>7.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30840775\" target=\"_blank\" rel=\"noreferrer noopener\">Epidemiological Description, Case-Fatality Rate, and Trends of Hantavirus Pulmonary Syndrome: 9 Years of Surveillance in Argentina.<\/a><\/p>\n\n\n\n<p>Journal of Medical Virology. 2019.&nbsp;Alonso DO, Iglesias A, Coelho R, et al.<\/p>\n\n\n\n<p>8.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39024823\" target=\"_blank\" rel=\"noreferrer noopener\">Critical Care Management of Hantavirus Cardiopulmonary Syndrome. A Narrative Review.<\/a><\/p>\n\n\n\n<p>Journal of Critical Care. 2024.&nbsp;Ulloa-Morrison R, Pavez N, Parra E, et al.<\/p>\n\n\n\n<p>9.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21853152\" target=\"_blank\" rel=\"noreferrer noopener\">In Vitro and in Vivo Activity of Ribavirin Against Andes Virus Infection.<\/a><\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"\" width=\"18\" height=\"18\" srcset=\"\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fplos.org%2F%26sz%3D32&amp;w=32&amp;q=75 1x, \/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fplos.org%2F%26sz%3D32&amp;w=48&amp;q=75 2x\" src=\"https:\/\/www.openevidence.com\/_next\/image?url=https%3A%2F%2Fwww.google.com%2Fs2%2Ffavicons%3Fdomain%3Dhttps%3A%2F%2Fplos.org%2F%26sz%3D32&amp;w=48&amp;q=75\">PloS One. 2011.&nbsp;Safronetz D, Haddock E, Feldmann F, Ebihara H, Feldmann H.<\/p>\n\n\n\n<p>10.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37901807\" target=\"_blank\" rel=\"noreferrer noopener\">Hantavirus: An Overview and Advancements in Therapeutic Approaches for Infection.<\/a><\/p>\n\n\n\n<p>Frontiers in Microbiology. 2023.&nbsp;Afzal S, Ali L, Batool A, et al.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Profundizamos en la virolog\u00eda y epidemiolog\u00eda del hantavirus cepa Andes, el pat\u00f3geno responsable de la crisis sanitaria en el MV Hondius. Un an\u00e1lisis detallado sobre su letalidad del 40%, su capacidad \u00fanica de transmisi\u00f3n interhumana y los protocolos de soporte vital (ECMO) necesarios para enfrentar el S\u00edndrome Cardiopulmonar por Hantavirus en entornos cr\u00edticos.<\/p>\n","protected":false},"author":1,"featured_media":860,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[276,277],"tags":[789,783,788,790,786,787,785,784,791],"class_list":["post-859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina","category-salud","tag-control-de-infecciones","tag-epidemiologia","tag-hantavirus","tag-medicina-critica","tag-salud-publica","tag-scph","tag-virologia","tag-virus-andes","tag-zoonosis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hantavirus - Ciencia y Tecnologia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hantavirus - Ciencia y Tecnologia\" \/>\n<meta property=\"og:description\" content=\"Profundizamos en la virolog\u00eda y epidemiolog\u00eda del hantavirus cepa Andes, el pat\u00f3geno responsable de la crisis sanitaria en el MV Hondius. Un an\u00e1lisis detallado sobre su letalidad del 40%, su capacidad \u00fanica de transmisi\u00f3n interhumana y los protocolos de soporte vital (ECMO) necesarios para enfrentar el S\u00edndrome Cardiopulmonar por Hantavirus en entornos cr\u00edticos.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/\" \/>\n<meta property=\"og:site_name\" content=\"Ciencia y Tecnologia\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-06T13:27:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-06T13:30:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1408\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"david\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"david\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/\"},\"author\":{\"name\":\"david\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#\\\/schema\\\/person\\\/b76777e3c0d2d08ea263068461c90d4b\"},\"headline\":\"Hantavirus\",\"datePublished\":\"2026-05-06T13:27:19+00:00\",\"dateModified\":\"2026-05-06T13:30:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/\"},\"wordCount\":1576,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#\\\/schema\\\/person\\\/b76777e3c0d2d08ea263068461c90d4b\"},\"image\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/wp-content\\\/uploads\\\/2026\\\/05\\\/Hantavirus.jpg\",\"keywords\":[\"Control de Infecciones\",\"Epidemiolog\u00eda\",\"Hantavirus\",\"Medicina Cr\u00edtica\",\"Salud P\u00fablica\",\"SCPH\",\"Virolog\u00eda\",\"Virus Andes\",\"Zoonosis\"],\"articleSection\":[\"Medicina\",\"Salud\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/\",\"url\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/\",\"name\":\"Hantavirus - Ciencia y Tecnologia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/wp-content\\\/uploads\\\/2026\\\/05\\\/Hantavirus.jpg\",\"datePublished\":\"2026-05-06T13:27:19+00:00\",\"dateModified\":\"2026-05-06T13:30:55+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#primaryimage\",\"url\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/wp-content\\\/uploads\\\/2026\\\/05\\\/Hantavirus.jpg\",\"contentUrl\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/wp-content\\\/uploads\\\/2026\\\/05\\\/Hantavirus.jpg\",\"width\":1408,\"height\":768},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/hantavirus\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hantavirus\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#website\",\"url\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/\",\"name\":\"Ciencia y Tecnologia\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#\\\/schema\\\/person\\\/b76777e3c0d2d08ea263068461c90d4b\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\\\/#\\\/schema\\\/person\\\/b76777e3c0d2d08ea263068461c90d4b\",\"name\":\"david\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g\",\"caption\":\"david\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g\"},\"sameAs\":[\"https:\\\/\\\/cienciaytecnology.com\\\/wordpress\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hantavirus - Ciencia y Tecnologia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/","og_locale":"es_ES","og_type":"article","og_title":"Hantavirus - Ciencia y Tecnologia","og_description":"Profundizamos en la virolog\u00eda y epidemiolog\u00eda del hantavirus cepa Andes, el pat\u00f3geno responsable de la crisis sanitaria en el MV Hondius. Un an\u00e1lisis detallado sobre su letalidad del 40%, su capacidad \u00fanica de transmisi\u00f3n interhumana y los protocolos de soporte vital (ECMO) necesarios para enfrentar el S\u00edndrome Cardiopulmonar por Hantavirus en entornos cr\u00edticos.","og_url":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/","og_site_name":"Ciencia y Tecnologia","article_published_time":"2026-05-06T13:27:19+00:00","article_modified_time":"2026-05-06T13:30:55+00:00","og_image":[{"width":1408,"height":768,"url":"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg","type":"image\/jpeg"}],"author":"david","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"david","Tiempo de lectura":"8 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#article","isPartOf":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/"},"author":{"name":"david","@id":"https:\/\/cienciaytecnology.com\/wordpress\/#\/schema\/person\/b76777e3c0d2d08ea263068461c90d4b"},"headline":"Hantavirus","datePublished":"2026-05-06T13:27:19+00:00","dateModified":"2026-05-06T13:30:55+00:00","mainEntityOfPage":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/"},"wordCount":1576,"commentCount":0,"publisher":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/#\/schema\/person\/b76777e3c0d2d08ea263068461c90d4b"},"image":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#primaryimage"},"thumbnailUrl":"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg","keywords":["Control de Infecciones","Epidemiolog\u00eda","Hantavirus","Medicina Cr\u00edtica","Salud P\u00fablica","SCPH","Virolog\u00eda","Virus Andes","Zoonosis"],"articleSection":["Medicina","Salud"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/","url":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/","name":"Hantavirus - Ciencia y Tecnologia","isPartOf":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#primaryimage"},"image":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#primaryimage"},"thumbnailUrl":"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg","datePublished":"2026-05-06T13:27:19+00:00","dateModified":"2026-05-06T13:30:55+00:00","breadcrumb":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#primaryimage","url":"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg","contentUrl":"https:\/\/cienciaytecnology.com\/wordpress\/wp-content\/uploads\/2026\/05\/Hantavirus.jpg","width":1408,"height":768},{"@type":"BreadcrumbList","@id":"https:\/\/cienciaytecnology.com\/wordpress\/hantavirus\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/cienciaytecnology.com\/wordpress\/"},{"@type":"ListItem","position":2,"name":"Hantavirus"}]},{"@type":"WebSite","@id":"https:\/\/cienciaytecnology.com\/wordpress\/#website","url":"https:\/\/cienciaytecnology.com\/wordpress\/","name":"Ciencia y Tecnologia","description":"","publisher":{"@id":"https:\/\/cienciaytecnology.com\/wordpress\/#\/schema\/person\/b76777e3c0d2d08ea263068461c90d4b"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cienciaytecnology.com\/wordpress\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":["Person","Organization"],"@id":"https:\/\/cienciaytecnology.com\/wordpress\/#\/schema\/person\/b76777e3c0d2d08ea263068461c90d4b","name":"david","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/secure.gravatar.com\/avatar\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g","caption":"david"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/a9d8ccd92847e24d772422bc56934157f705784123e5b11a9724d44add16e6bb?s=96&d=mm&r=g"},"sameAs":["https:\/\/cienciaytecnology.com\/wordpress"]}]}},"_links":{"self":[{"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/posts\/859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/comments?post=859"}],"version-history":[{"count":2,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/posts\/859\/revisions"}],"predecessor-version":[{"id":863,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/posts\/859\/revisions\/863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/media\/860"}],"wp:attachment":[{"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/media?parent=859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/categories?post=859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cienciaytecnology.com\/wordpress\/wp-json\/wp\/v2\/tags?post=859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}